Séminaire exceptionnel sur la maladie de Parkinson

Séminaire exceptionnel sur la maladie de Parkinson

Le professeur Professeur Seung-Jae Lee est invité par par Ronald Melki "Team Protein folding in vivo and conformational diseases"
www.lebs.cnrs-gif.fr/en/teams/melki.html

 

Misfolding and intracellular aggregation of a-synuclein are through to be crucial factors in the pathogenesis of Lewy body diseases (LBD), such as Parkinson disease. However, the pathogenic modifications of this protein and the mechanism underlying its activity have not been fully characterized. Recent studies suggest that very low levels of a-synuclein are released from neuronal cells by unconventional exocytosis and that this extracellular a-synuclein contributes to the major pathological features of LBD, such as neurodegeneration, progressive spreading of a-synuclein pathology, and neuroinflammation. In this talk, I will review a rapidly growing body of literature on possible mechanisms by which extracellular a-synuclein contributes to LBD pathology, and discuss therapeutic approaches to target this form of a-synuclein to halt the progression of the LBD.